Health effects classification and its role in the derivation of minimal risk levels: hepatic effects.
نویسندگان
چکیده
The Agency for Toxic Substances and Disease Registry (ATSDR) derives health based guidance values called minimal risk levels (MRLs) to assist with assessment of risks posed by exposures to hazardous chemicals. Current MRLs are posted on ATSDR's web site (www.atsdr.cdc.gov). From the total 326 MRLs currently posted, 79 MRLs are based on hepatic endpoints. The paper reports on endpoints used for the derivation of these MRLs and the use of uncertainty factors. It also describes the ranking of effects into less serious and serious categories as described in ATSDR's Guidance for Developing Toxicological Profiles.
منابع مشابه
Health effects classification and its role in the derivation of minimal risk levels: reproductive and endocrine effects.
The Agency for Toxic Substances and Disease Registry (ATSDR) derives health-based guidance values called minimal risk levels (MRLs) to assist with assessment of risks posed by exposures to hazardous chemicals. From the total of 326 MRLs currently posted on ATSDR's web site (www.atsdr.cdc.gov), 14 and 5 MRLs are based on reproductive and endocrine endpoints, respectively. The paper also describe...
متن کاملHealth effects classification and its role in the derivation of minimal risk levels: neurological effects.
The agency for Toxic Substances and Disease Registry (ATSDR) uses substance-specific minimal risk levels (MRLs) to assist in evaluating public health risks associated with exposure to hazardous substances. By definition, "MRLs are estimates of daily human exposure to a chemical that are likely to be without an appreciable risk of adverse noncancer health effects over a specified duration of exp...
متن کاملEffects of Urtica dioica supplementation on blood lipids, hepatic enzymes and nitric oxide levels in type 2 diabetic patients: A double blind, randomized clinical trial
Objective: Oxidative stress plays an important role in the development of diabetic complications including metabolic abnormality-induced diabetic micro-vascular and macro-vascular complications. Urtica dioica L. (U. dioica) has been traditionally used in Iranian medicine as an herbal remedy for hypoglycemic or due to its anti-inflammatory properties. The aim of the present study was to evaluate...
متن کاملHealth effects classification and its role in the derivation of minimal risk levels: renal effects.
The Agency for Toxic Substances and Disease Registry (ATSDR) derives minimal risk levels (MRLs) for priority hazardous substances. MRLs are health guidance values intended to serve as screening levels for health assessors to select contaminants of concern and to assess potential health effects at hazardous waste sites and areas affected by unplanned releases. Current MRLs are published in ATSDR...
متن کاملHealth effects classification and its role in the derivation of minimal risk levels: immunological effects.
The Agency for Toxic Substances and Disease Registry (ATSDR) derives health-based guidance values known as minimal risk levels (MRLs). By definition, an MRL is a substance-specific estimate of the daily human exposure to a substance that is likely to be without an appreciable risk of adverse, noncancer effects over a specified duration of exposure. MRLs are preferentially derived from human stu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Regulatory toxicology and pharmacology : RTP
دوره 42 2 شماره
صفحات -
تاریخ انتشار 2005